block diagram editor in simbiology (MathWorks Inc)
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Block Diagram Editor In Simbiology, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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1) Product Images from "A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma"
Article Title: A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma
Journal: Frontiers in Immunology
doi: 10.3389/fimmu.2021.662528
Figure Legend Snippet: General Workflow of the Project. In order to achieve the aims and objectives of this study, integrated data analysis of microarray and RNA-seq were performed for cSCC and psoriasis. From differential expression analysis, common DEGs between psoriasis and cSCC were identified that are proposed as potential biomarkers and therapeutic targets for both the diseases. Pathway analysis was then performed to analyze the disrupted pathways and their possible relation with the disease. The significant pathways (at p-value <= 0.05) from every dataset were then compared for common pathway. As a result of this comparison, one common pathway, named IL-17 signaling pathway, was identified. Afterwards, quantitative systems biology was implemented to analyze the results at a holistic level. A sub-section of complete IL-17 pathway was modeled by using SimBiology application in Matlab . The average expressions values of DEGs that were present in the pathway were calculated for microarray datasets of psoriasis and cSCC. The model was then simulated by adding the average expression values. After simulation of the model, sensitivity analysis was performed to analyze the response of the biological processes to model quantities (DEGs and genes). Sensitivity analysis of the biological processes of both psoriasis and cSCC revealed significant genes that might lead psoriasis to cancer and could also be proposed as potential biomarkers and therapeutic targets of both the diseases.
Techniques Used: Microarray, RNA Sequencing, Quantitative Proteomics, Biomarker Discovery, Comparison, Expressing